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Results for "

prion protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Apoptosis (1) Fluorescent Dye (1) Phosphatase (2) Reactive Oxygen Species (1) Tau Protein (1)
By Research Areas:	Cancer (1) Infection (7) Inflammation/Immunology (2) Neurological Disease (4)

10

Inhibitors & Agonists

3

Peptides

2

Inhibitory Antibodies

3

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

BiCAPPA	Others	Infection
BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrP ^Sc) from scrapie-infected cells, with an EC₅₀ of 0.32 μM .

TCS PrP Inhibitor 13	Apoptosis	Infection Cancer
TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrP ^C) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC₅₀ value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis .

NSC47924	Others	Infection
NSC47924 is a laminin receptor (LR) inhibitor. NSC47924 affects 37/67 kDa LR cell surface localization and interaction with the cellular prion protein. NSC47924 can be used for testing prion diseases .

PrPSc-IN-1	Fluorescent Dye	Neurological Disease
PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrP ^Sc, inhibits its accumulation, with an IC₅₀ of 1.6 μM. Anti-prion activity .

Tau protein aggregation-IN-1	Tau Protein	Neurological Disease
Tau protein aggregation-IN-1 (Compound 0c) is a Tau protein aggregation inhibitor. Tau protein aggregation-IN-1 can be used in the study of protein folding disorders such as Alzheimer's disease, dementia, Parkinson's disease, Huntington's disease and prion-based spongiform encephalopathies .

Icerguastat Sephin1; IFB-088	Phosphatase	Infection Inflammation/Immunology
Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect .

HY-132927A

Salpyran hydrochloride

Others Others

Salpyran is a Cu(II) selective chelator with therapeutic potential .

Salpyran dihydrochloride	Reactive Oxygen Species	Inflammation/Immunology
Salpyran dihydrochloride is a Cu(II) selective chelator with therapeutic potential. Salpyran dihydrochloride prevents the formation of reactive oxygen species from the binary Cu(II)/H₂O₂ system .

Icerguastat Carbonate Sephin1 Carbonate; IFB-088 Carbonate	Phosphatase	Infection
Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect .

Emrusolmin Anle138b	Amyloid-β	Neurological Disease
Emrusolmin (Anle138b), an oligomeric aggregation inhibitor, blocks the formation of pathological aggregates of prion protein (PrPSc) and of α-synuclein (α-syn). Emrusolmin strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression in vivo. Emrusolmin has low toxicity and an excellent oral bioavailability and blood-brain-barrier penetration. Emrusolmin blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology .

Cat. No.	Product Name	Target	Research Area

PrP (106-126) prion protein (106-126)	Peptides	Infection
PrP (106-126) is a peptide corresponding to the prion protein (PrP) amyloidogenic region, and its biochemical properties resemble the infectious form of prion protein.

Prion Protein (106-126) (human) (scrambled)	Peptides	Neurological Disease
Prion Protein (106-126) (human) (scrambled) is a scrambled sequence of Prion Protein (106-126). Prion Protein (106-126) (human) (scrambled) with a random sequence of the amino acids that are the same as the active fragment. Prion Protein (106-126) (human) (scrambled) usually used as a negative control .

Amyloid-Forming peptide GNNQQNY	Peptides	Others
Amyloid-Forming peptide GNNQQNY is a biological active peptide. (This is a heptapeptide from the N-terminal prion-determining domain of the yeast protein Sup35 that forms amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stage of aggregation. The GNNQQNY dimer forms three stable sheet structures. in-register parallel, off-register parallel, and anti-parallel. The in-register parallel dimer, which is close to the amyloid beta-sheet structure, has few interpeptide hydrogen bonds, making hydrophobic interactions more important and increasing the conformational entropy compared to the anti-parallel sheet.)

Cat. No.	Product Name	Target	Research Area

*Anti-Mouse/Human PrP/prion* protein Antibody (TW1)**	Inhibitory Antibodies	Others
Anti-Mouse/Human PrP/prion protein Antibody (TW1) is a mouse-derived IgG2a type antibody inhibitor, targeting to mouse/human PrP/prion protein.

HY-P990030

Ralzapastotug

AB-308
Inhibitory Antibodies Infection

Ralzapastotug (AB-308) is a monoclonal antibody targeting amino acids 106-126 of the cellular prion protein PrP ^C .

Species:	Human (2) Mouse (1)
Tag:	His (1) Fc (2)
Source:	HEK293 (3)

Cat. No.	Compare	Product Name	Species	Source

	PRND Protein, Human (HEK293, His) prion-like protein doppel; PrPLP; prion protein 2; PRND; DPL	Human	HEK293
	PRND protein is crucial for orchestrating the normal acrosome reaction, ensuring male fertility, and exhibiting copper ion binding capabilities. Its dual functionality highlights its significance in the intricate molecular mechanisms governing male reproductive functions and copper ion interactions. PRND Protein, Human (HEK293, His) is the recombinant human-derived PRND protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PRND Protein, Human (HEK293, His) is 126 a.a., with molecular weight of 20-29 kDa.

	PRNP/CD230 Protein, Human (HEK293, Fc) Major prion protein; CD230; ALTPRP; PRIP; PRP	Human	HEK293
	Although its primary function is unknown, the PRNP/CD230 protein has been implicated in multiple neuronal processes, including neuronal development, synaptic plasticity, and myelin homeostasis. PRNP acts as an agonist of the ADGRG6 receptor and promotes the maintenance of myelin. PRNP/CD230 Protein, Human (HEK293, Fc) is the recombinant human-derived PRNP/CD230 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PRNP/CD230 Protein, Human (HEK293, Fc) is 207 a.a., with molecular weight of ~57.4 kDa.

	PRNP/CD230 Protein, Mouse (HEK293, Fc) Major prion protein; PrP; ALTPRP; PRIP; PRP; PRNP	Mouse	HEK293
	The PRNP/CD230 protein is involved in multiple cellular processes and may affect neuronal development, synaptic plasticity, and myelin maintenance. It promotes myelin homeostasis, induces apoptosis, and interacts with other proteins. PRNP/CD230 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PRNP/CD230 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PRNP/CD230 Protein, Mouse (HEK293, Fc) is 208 a.a., with molecular weight of 60-68 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P81980

Prion Protein Antibody (YA1725)

CJD; GSS; PrP; PRNP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; prion protein; PrP27-30; PrP33-35C
WB, IHC-P Human, Mouse, Rat

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